In the course of the twentieth century, structure became a central category of thought across a wide array of sciences. From linguistics to anthropology, psychoanalysis and history, the epistemic aim of analyzing structures guided a diverse range of research programs. And yet, the quest for immaterial or timeless structures that might underlie, order, organize—let alone determine—more readily perceptible domains of reality today appears strange, even suspicious, to most cultural anthropologists and historians of science. To grapple with these changes in the epistemic virtues guiding the work of anthropologists and their historians, as well as structures’ many afterlives outside of the academy, this Special Focus Section aims to adopt a broader historical view of the phenomenon by shifting analytic attention away from specific structuralist texts, intellectuals, and institutions toward structures as epistemic things in the history of anthropology and adjacent domains of inquiry.